Asepsis was a tool developed especially to remove .DS_store but as of the introduction of SIP in OSX this has become more problematic.
Thankfully, Mike Greiling has written up a nice guide with step-by-step instructions on how to continue to use Asepsis without compromising security.
IMPORTANT: If you are using XtraFinder at Step #4 you will want to use the following command at Step #4 in order to ensure XtraFinder continues to work as expected.
csrutil enable --without debug